Introduction to Aspen Chromatography

• Gain first-hand experience and confidence in working within the Aspen Chromatography simulation environment
• Apply Aspen Chromatography to build and execute simulations rapidly
• Enhance the customer’s ability to succeed in their application of Aspen Chromatography, and thus reap the technical and business benefits as soon as possible

• Instruction on basic topics
• Discussion about the general approach and the key elements for successful simulations
• Demonstrations of features
• Instructor-guided exercises
• Hands-on workshops that apply learned concepts
• Detailed course notes

• No prior knowledge of dynamic simulation required
• No prior experience of Aspen Chromatography is required
• Some familiarity with basic Microsoft® Windows skills are helpful
• Understanding of industrial adsorption/ chromatography processes are helpful
• EAP2311 Building Custom Simulation Models using Aspen Custom Modeler

• Graphical User Interface Basics and Physical Properties
• Learn to access and navigate the Aspen Chromatography graphical user interface
• Build flowsheets to simulate typical processes
• Create plots and tables to analyze simulation results
• Access runtime and solver options to ensure simulation convergence 
• Workshop (Demonstration) Batch Injection of Sugars

• Batch Column Basics
• Discuss and review the batch column capabilities
• Define the column assumptions required to establish a simulation
• Show how to create a flowsheet using the batch column and other supporting models
• Review results and chromatography report
• Complete the workshop to gain familiarity with the batch column simulation setup and analysis of a chromatographic separation of D- & L- threonine
• Workshop: Chromatographic Separation of D- & L- Threonine

• Cyclic Operation
• Demonstrate how to use the Cycle Organizer to create cyclic processes
• Gain familiarity with simulating successive batch injection
• Gain familiarity with simulating successive batch injection with product collection
• Workshop: Run successive batch injection using the Cycle Organizer

• Simulated Moving Bed (SMB) and True Moving Bed (TMB)Examine the TMB/SMB capabilities of Aspen Chromatography
• Set up and configure TMB/SMB flowsheets
• Demonstrate how to use the SMB flowrate optimizer
• Recognize what results are available and how to interpret them
• Discuss how to use the results predicted from TMB operation to initialize SMB operation to achieve faster convergence to cyclic steady-state
• Complete workshop to gain familiarity with separation of D- and L- threonine enantiomers using a continuous counter-current separator
• Workshop: Separation of D- and L- Threonine Enantiomers Using A Continuous Counter-Current Separator

• User Correlations Through Flowsheet ConstraintsIdentify and explain flowsheet constraints
• Determine when flowsheet constraints can be used
• Identify and explain custom isotherms
• Demonstrate how to write custom isotherms using the modeling language
• Complete the workshop to create the extended Langmuir isotherm as a flowsheet constraint
• Workshop: Create the Extended Langmuir Isotherm as a Flowsheet Constraint

• Size Exclusion Chromatography
• Discuss and review Size Exclusion Chromatography (SEC):

- Advantages and disadvantages of SEC

- Factors that affect the performance of SEC

- Aspen Chromatography assumptions for modeling SEC

Demonstration to create and execute a SEC simulation (Batch SEC of Myoglobin and Ovalbumin)

• Affinity Chromatography
• Discuss and review Affinity Chromatography:

- Advantages and disadvantages of Affinity Chromatography

- Operational steps of Affinity Chromatography

- How Aspen Chromatography can be used to model Affinity Chromatography systems

- How to enable and write reactions for the column model

• Demonstration to create and execute an Affinity Chromatography simulation (Affinity Chromatography by User Reactions)

• Bulk Liquid Operation
• Examine the difference between the trace and bulk liquid component material balances
• Discuss implications when using the bulk liquid mode:
• Workshop: Investigate Xylenes separation using True Moving Bed (TMB)

• Ion Exchange Operation
• Recognize the configuration and specification of ion exchange models
• Identify the available isotherms
• Create batch and gradient elution ion-exchange flowsheets
• Define gradient elution strategies using Cycle Organizer
• Complete the workshop to gain familiarity with linear gradient elution of the proteins ovalbumin and lactoglobulin
• Workshop: Linear Gradient Elution of the Proteins Ovalbumin and Lactoglobulin

• Parameter Estimation
• Discuss and review parameter estimation
• Review the initial guess strategy as it relates to parameter estimation
• Estimate isotherm parameters using steady-state estimation
• Demo to gain familiarity with fitting isotherm parameters to static measurements
• Estimate isotherm parameters using dynamic estimation
• Complete the workshop to gain familiarity with fitting isotherm parameters to dynamic breakthrough measurements
• Workshop: The Fitting of Isotherm Parameters to Dynamic Breakthrough Measurements

• Diagnostic and Solution Methods
• Discuss and review issues in convergence
• Provide general advice on troubleshooting

- Diagnostic tools

- Solver settings