Introduction to Aspen Chromatography

Learn how to set up and solve the dynamic simulation problems in chromatography. Gain first-hand experience in working within the Aspen Chromatography simulation environment. Apply Aspen Chromatography to build and execute simulations rapidly.

Audience:

Scientists and engineers involved in the design, operation, optimization, and analysis of industrial chromatographic processes such as batch or gradient elution chromatography and simulated moving bed.

Training Details

  • Course Id:

    EAP289

  • Duration:

    2 day(s)

  • CEUs Awarded:

    1.4

  • Level:

    Intermediate

Benefits

  • Gain first-hand experience and confidence in working within the Aspen Chromatography simulation environment
  • Apply Aspen Chromatography to build and execute simulations rapidly
  • Enhance the customer’s ability to succeed in their application of Aspen Chromatography, and thus reap the technical and business benefits as soon as possible

Approach

  • Instruction on basic topics
  • Discussion about the general approach and the key elements for successful simulations
  • Demonstrations of features
  • Instructor-guided exercises
  • Hands-on workshops that apply learned concepts
  • Detailed course notes

Pre-requisites

  • No prior knowledge of dynamic simulation required
  • No prior experience of Aspen Chromatography is required
  • Some familiarity with basic Microsoft® Windows skills are helpful
  • Understanding of industrial adsorption/ chromatography processes are helpful
  • EAP2311 Building Custom Simulation Models using Aspen Custom Modeler

Agenda

Graphical User Interface Basics and Physical Properties
  • Learn to access and navigate the Aspen Chromatography graphical user interface
  • Build flowsheets to simulate typical processes
  • Create plots and tables to analyze simulation results
  • Access runtime and solver options to ensure simulation convergence  

Batch Column Basics
  • Discuss and review the batch column capabilities
  • Define the column assumptions required to establish a simulation
  • Show how to create a flowsheet using the batch column and other supporting models
  • Review results and chromatography report
  • Complete the workshop to gain familiarity with the batch column simulation setup and analysis of a chromatographic separation of D- & L- threonine
  • Workshop: Chromatographic Separation of D- & L- Threonine
  • Workshop(Optional) Batch Injection of Sugars

Cyclic Operation
  • Demonstrate how to use the Cycle Organizer to create cyclic processes
  • Gain familiarity with simulating successive batch injection
  • Gain familiarity with simulating successive batch injection with product collection

Simulated Moving Bed (SMB) and True Moving Bed (TMB)
  • Examine the TMB/SMB capabilities of Aspen Chromatography
  • Set up and configure TMB/SMB flowsheets
  • Demonstrate how to use the SMB flowrate optimizer
  • Recognize what results are available and how to interpret them
  • Discuss how to use the results predicted from TMB operation to initialize SMB operation to achieve faster convergence to cyclic steady-state
  • Complete workshop to gain familiarity with separation of D- and L- threonine enantiomers using a continuous counter-current separator
  • Workshop: Separation of D- and L- Threonine Enantiomers Using A Continuous
  • Counter-Current Separator

User Correlations Through Flowsheet Constraints
  • Identify and explain flowsheet constraints
  • Determine when flowsheet constraints can be used
  • Identify and explain custom isotherms
  • Demonstrate how to write custom isotherms using the modeling language
  • Complete the workshop to create the extended Langmuir isotherm as a flowsheet constraint
  • Workshop: Create the Extended Langmuir Isotherm as a Flowsheet Constraint

Size Exclusion Chromatography
  • Discuss and review Size Exclusion Chromatography (SEC):
  • Advantages and disadvantages of SEC
  • Factors that affect the performance of SEC
  • Aspen Chromatography assumptions for modeling SEC
  • Demonstration to create and execute a SEC simulation (Batch SEC of Myoglobin and Ovalbumin)

Affinity Chromatography
  • Discuss and review Affinity Chromatography:
  • Advantages and disadvantages of Affinity Chromatography
  • Operational steps of Affinity Chromatography
  • How Aspen Chromatography can be used to model Affinity Chromatography systems
  • How to enable and write reactions for the column model
  • Demo to create and execute an Affinity Chromatography simulation (Affinity Chromatography by User Reactions)

Bulk Liquid Operation
  • Examine the difference between the trace and bulk liquid component material balances
  • Discuss implications when using the bulk liquid mode:
  • Demonstration to gain familiarity with Xylene separation using True Moving Bed (TMB)

Ion Exchange Operation
  • Recognize the configuration and specification of ion exchange models
  • Identify the available isotherms
  • Create batch and gradient elution ion-exchange flowsheets
  • Define gradient elution strategies using Cycle Organizer
  • Complete the workshop to gain familiarity with linear gradient elution of the proteins ovalbumin and lactoglobulin
  • Workshop: Linear Gradient Elution of the Proteins Ovalbumin and Lactoglobulin

Parameter Estimation
  • Discuss and review parameter estimation
  • Review the initial guess strategy as it relates to parameter estimation
  • Estimate isotherm parameters using steady-state estimation
  • Demo to gain familiarity with fitting isotherm parameters to static measurements
  • Estimate isotherm parameters using dynamic estimation
  • Complete the workshop to gain familiarity with fitting isotherm parameters  to dynamic breakthrough measurements
  • Workshop: The Fitting of Isotherm Parameters  to Dynamic Breakthrough Measurements

Diagnostic and Solution Methods
  • Discuss and review issues in convergence
  • Provide general advice on troubleshooting
  • Diagnostic tools
  • Solver settings

Register for a Class

Date Class Type Location Price Language
Date(s): 10/27/2021 - 10/28/2021 Type: Public Virtual Location: Virtual-Americas Price: (USD) 1400.00 Language: English Register

Aspen Technology, Inc. awards Continuing Education Units (CEUs) for training classes conducted by our organization. One CEU is granted for every 10 hours of class participation.